Helicoidal structure in the Endoplasmic Reticulum and chiral pattern of actin fibres

We construct theoretical, physics-based models for the formation, shaping and function of sub-cellular structures. Primarily, we study the morphology of membrane surfaces in the endoplasmic reticulum (ER); and self-arrangement and force production in the actin cytoskeleton.

The lab research is inherently interdisciplinary: we use physics considerations and computer simulations, while working in close collaboration with experimental biologists in an effort to create models that are relevant to understanding the actual biological systems. In contrast with information-focused theoretical biology, we study the “blue collar”, mechanical, role of proteins and lipids.